The cytokine‐cytokine receptor interaction pathway is enriched in pancreatic adenocarcinoma. PAAD: Pancreatic adenocarcinoma ESCA: Esophageal carcinoma STAD: Stomach adenocarcinoma HNSC: Head and neck squamous cell carcinoma LUAD: Lung adenocarcinoma LUSC: Lung squamous cell carcinoma LIHC: Liver hepatocellular carcinoma COAD: Colon adenocarcinoma READ: Rectum adenocarcinoma LAML: Acute myeloid leukemia PRAD: Prostate adenocarcinoma BRCA: Breast invasive carcinomaįigure S3. Genes that are specifically upregulated or downregulated genes in one tumor type (absolute values of fold‐change > 2.0 and q‐value < 0.01 ANOVA) are shown in red and blue, respectively. The resulting numbers of genes encoding predicted secreted proteins were filtered based on the Human Protein Atlas secretome data 27 ( ).
Differential expression levels were calculated using the web‐based tool Gene Expression Profiling Analysis (GEPIA, ) 32. Heatmap of the mean expression levels of specifically upregulated (a) or downregulated (b) secretome genes in each tumor type compared with corresponding matched normal TCGA and GTEx tissues. Exclusive upregulated genes within tumor types.
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